She's the second first lady -- after Hillary Clinton -- to appear on the front of the magazine, the Washington Post reports.
In a photo taken by Annie Leibovitz, Obama poses in a magenta Jason Wu gown on a sofa at the Hay-Adams Hotel, where her family stayed for several days before moving into the White House. (Wu also designed her one-shouldered inaugural ball gown.)
See what celebs wore to the inaugural balls.
She's also pictured hard at work -- surrounded by a notepad, pen, laptop, a cup of tea, and on the phone -- in a black dress by designer Narciso Rodriguez.
The magazine's editor, Anna Wintour, says, "It's inspiring to see our first lady so serene and secure in her personal style."
See what first ladies through the years have worn to the inaugural balls.
The mother of two tells Andre Leon Talley, who wrote the story, that she's focusing on settling in Washington, D.C., trying to find a church and helping her daughters become adjusted.
"I'm going to try to take them to school every morning -- as much as I can," she says. "But there's also a measure of independence. And obviously there will be times I won't be able to drop them off at all. I like to be a presence in my kids' school. I want to know the teacher; I want to know the other parents."
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Her DNC blue dress
At church with family in white
Her black and red dress for Obama's presidential win
Wearing gold for a press conference
Shining in yellow on Jay Leno
At a rally in an off-red outfit
Her infamous White House Black Market dress she wore on "The View"
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