Never mind that the Arena comedy, which airs on HBO in the US, is a veritable TV smorgasbord of sex and swearing, smattered with occasional nudity.
"It's a family show. You wouldn't know it at first glance, but if you scratch below the surface and that superficial partying and the 'T and A', you get into something that is family oriented," Grenier says.
"People come up to me all the time and say, 'Your show is the one time me and my family come together'.
"I think that is the reason the show has such a far-reaching scope. People respond to that."
That may seem a bit of a stretch. In the third season, Grenier's character Vincent Chase and his manager Eric "E" Murphy (Kevin Connolly) visit director Billy Walsh on the set of an adult movie he is shooting.
But there's more to Entourage than meets the eye.
The show centres on aspiring actor Vince's path to movie fame and glory. As well as being an insight into the cutthroat world of Hollywood, it's often a moving take on the bonds of friendship.
Vince's entourage - Eric, Turtle (Jerry Ferrera) and Johnny "Drama" Chase (Kevin Dillon) - are his buddies from when he was a nobody back in Queens, New York.
Of course, it's a distinctly male perspective we see and most females in the show are potential sexual conquests.
Grenier makes no apologies for the "alpha male" slant.
"Men are happy to know that's expressed. It speaks to them and their experience," he argues.
"Women can appreciate the glimpse into the male psyche. They get to know the men they love so much."
Season four of Entourage is currently showing in Australia.
Most of the action centres on the gang's struggles to get their movie project Medellin off the ground. As usual, Walsh the director is making life difficult for all concerned, especially E.
"He's definitely an auteur, and an unstable one at that," says Grenier.
"That's one of the conflicts, not knowing whether the gamble with the movie will pay off. But a lot of the time, this business (Hollywood) is a gamble. You can make one wrong move and it could it be a disaster. But without risk there is no reward."
Ultimately, because of the friendship between the stars, if the show were to go pear-shaped and they ended up with nothing but the shirts on their backs, you get the sense that they wouldn't mind that much.
"I think that's why the show is so dynamic and successful," says Grenier. "It holds a mirror up to society and consumerism and at the same time has some great values."
Again with the family values argument.
Grenier was recently in Australia to promote the show, and had his fair share of interested females knocking on his hotel door. But he maintains he is not the party man he is often painted as.
"People believe what they want to believe," he says.
Interestingly, Grenier says he is picking up on some of Vince's better traits.
"He's given me a lot of confidence and taught me how to manoeuvre successfully in certain situations. At the same time, I help him a lot. He's becoming environmentally friendly. He recycles."
Ah, celebrities just ain't what they used to be.
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