"I don't think so," Cox, 43, tells Us Weekly in its latest issue. "But I would never say 100 percent no."
And what would her Friends character, Monica Geller, be up to now?
"She's running her suburb and in charge of the PTA," hypothesized Cox, now the star of FX's Dirt. "She's driving Chandler crazy, and he's probably driving her crazy too."
And like Angelina Jolie and Johnny Depp, Cox plans to spend Christmas with her family — husband David Arquette, 36, and CoCo, 3 — "someplace warm" where "there will be no Santa Ana winds."
Tell Us: Would you watch a Friends reunion?
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Would you be interested in seeing a "Saved By The Bell" reunion?
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