Three years after his memorable couch-jumping episode, Winfrey will interview Cruise from his home in Telluride, Colorado, on May 2.
Then, Cruise will appear in her Chicago studio for a second taping on May 5.
The two-part show coincides with the 25th anniversary of Cruise's famous flick Risky Business.
Friends and colleagues will surprise him with taped messages, according to Harpo Productions.
Since his last appearance, Cruise wed Katie Holmes, and the couple welcomed daughter Suri — who just turned 2.
See the couple's most romantic moments here.
Tell Us: What should Oprah ask Tom?
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