Johnny Depp won two awards: Best Comedic Performance (for Pirates of the Caribbean: At World's End) and Best Villian (for Sweeney Todd). He beat out pregnant Angelina Jolie (Beowulf) for Best Villian.
Transformers was named the Best Movie.
Tom Cruise – who hosted a star-studded housewarming party Saturday night – showed up to present the MTV Generation achievement award to Adam Sandler.
"The man, the icon, the legend," Cruise said before Sandler performed his own version of "Nobody Does It Better."
Love Guru star Mike Myers hosted the awards.
Check out summer's hot movie couples here.
MTV Movie Awards winners:
BEST MOVIE
Transformers
BEST FEMALE PERFORMANCE
Ellen Page, Juno
BEST MALE PERFORMANCE
Will Smith, I Am Legend
BEST FIGHT
Sean Faris vs. Cam Gigandet, Never Back Down
BEST COMEDIC PERFORMANCE
Johnny Depp, Pirates of the Caribbean: At World's End
BREAKTHROUGH PERFORMANCE
Zac Efron, Hairspray
BEST VILLIAN
Johnny Depp, Sweeney Todd
BEST KISS
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